Phosphodiesterase Inhibitors

Neglected diseases, such as African Sleeping Sickness, have a big impact on human health and cause a major economic burden on developing countries. The parasites that cause sleeping sickness depend on enzymes called 'phosphodiesterases'. Distortion of the function of these enzymes is lethal for the parasites, which makes the enzyme a potential drug target.

Developing drugs for these diseases is commercially not feasible for a single company but the social need is very high. With support and advocacy of TI Pharma, an international partnership was started that brings together all relevant expertise to develop a possible treatment.


Drugs for Neglected Diseases initiative
University Bern
VU University Amsterdam
IOTA Pharmaceuticals
Royal Tropical Institute

For more information, please contact 
or call +31 71 332 2030


    “One of TI Pharma's big strengths is that it knows how to manage money. That's a skill that should be more widespread.”

    Tim Wells
    Chief Scientific Officer
    Medicines for Malaria Venture

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