Immunity for respiratory viruses
The aim of the project is to develop novel strategies to induce and monitor the humoral and cellular immunity that protects the host from respiratory virus infections.

Respiratory viruses are the cause of a large burden of disease in humans and although effective vaccines exist to protect against seasonal influenza, no vaccines are currently available for other important human respiratory viral diseases such as avian influenza, pandemic influenza and respiratory syncytial virus (RSV) infection.

Fast facts
Full project title: Development and application of novel strategies to induce and monitor humoral and cellular immunity to protect hosts from infection by respiratory viruses
Partners: Abbott, Erasmus MC (University Medical Center Rotterdam), Leiden University, Netherlands Vaccine Institute, MSD, OctoPlus NV, University Medical Center Groningen, Utrecht University, ViroClinics BV, and Virosome Biologicals BV 


An inflammation reaction is an attempt of the body to remove harmful stimuli such as damaged cells, irritants, viruses, bacteria or infectious agents. It should not be confused with infection, because an infection is caused by an external infectious agent whereas inflammation is the reaction against such agents. The symptoms of inflammation include redness, swelling, pain, fever, chills and fatigue. During an inflammation reaction, white blood cells are sent to the irritated areas in order to cleanse. Chemicals from the white blood cells are released to increase the blood flow, and thus these white blood cells, to the area. This blood flow results in the redness and warmth of the affected area. The inflammation can affect tissue, joints, but also organs. Diseases associated with inflammation are for example rheumatoid arthritis, inflammatory bowel disease, but also auto immune diseases. In this latter disease the body is triggered to use inflammation to attack foreign ‘intruders’ while in fact there are none. An overactive immune system thus causes the body to attack its own cells. Rheumatoid arthritis is the most common form of inflammatory disease, with 150.00 patients in the Netherlands in 2003 and inflammatory bowel disease makes a good second with approximately 35.000 patients.

PhD theses from this project

Mary van Helden (project T4-214)
Cellular immune responses to respiratory viruses

Christophe Barnier Quer (project T4-214)
Adjuvanted nanoparticulate seasonal influenza vaccines



“The experience that TI Pharma has from putting together partnerships to research neglected diseases is really valuable, because it applies across other therapeutic diseases.”

Tim Wells
Chief Scientific Officer
Medicines for Malaria Venture

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