Over the years, animal testing has become the standard for drug testing in pharmaceutical research. Recently questions have arisen about what exactly the predictive value of animal testing is. Is the predictive value of animal testing really as conclusive as is commonly believed? This project aims to determine whether there is a scientific basis for the use of animal testing in pharmaceutical research.

One of the ways this is investigated is by looking at drugs that have caused problems over the past fifteen years and checking whether these problems were already visible in the involved animal testing. It appears that animal testing for safety and drug quality assessment has been done as a matter of routine over the past decades, while in many cases no conclusive results were obtained. This seems to lead the way to a situation where in many, but not all cases the use of animals in drug testing can be avoided.

Fast facts
Full project title: The use of animals in pharmaceuticals Models
Start date: February 2009
End date: December 2013
Goal: Determining a scientific basis for the use of animal testing in pharmaceutical research
Principal investigator: Huub Schellekens, UU
Project size: 1st part: 2,5 FTE's, 2nd part: 5 FTE's
Partners: College ter beoordeling van geneesmiddelen, Life Sciences and Health (LSH), Nefarma

PhD theses from this project

“The experience that TI Pharma has from putting together partnerships to research neglected diseases is really valuable, because it applies across other therapeutic diseases.”

Tim Wells
Chief Scientific Officer
Medicines for Malaria Venture

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