Projects
Prediction and preclinical evaluation of the cardiotoxicity
In this project methods will be developed for early detection of the pro-arrhythmic potential of drug candidates in order to minimize cardiac safety risks. Drug-induced QT prolongation may lead to torsades de pointes, a potentially lethal arrhythmia. A number of drugs have been withdrawn from the market or have failed to obtain market authorization due to QT interval prolongation or due to lethal torsades de pointes. Therefore, this unwanted side effect must be recognized as early as possible in drug discovery, using in vitro high throughput systems.
Partners: Leiden University, NOTOX BV, Radboud University Nijmegen, Abbott, and University Medical Center Utrecht
Full project title: An integrated strategy for in silico prediction and preclinical evaluation of the cardiotoxicity of drug candidates