Projects
Ligand-Gated Ion Channel (LGIC) in drug discovery
The high-resolution crystal structure of the acetylcholine binding protein (AChBP) domain of the ligand-gated ion channel family forms the basis of this project and paves the way for structure-based drug design. New in-silico and in-vitro screening tools will be developed that cover computational chemistry, molecular biology, X-ray analysis, electrophysiology, PET-imaging and behavioral analysis. This research will fully exploit the possibilities to use AChBP as an in-silico and in-vitro tool in novel drug discovery.
Partners: Netherlands Cancer Institute, MSD, Abbott, and VU University Amsterdam
Full project title: New approaches for Ligand-Gated Ion Channel (LGIC) drug discovery