Projects
Parkinson disease and Alzheimer disease: from target to therapy
Parkinson and Alzheimer are neurodegenerative diseases with a considerable socio-economic burden. The immediate objectives of this project are identification and validation of potential drug targets, provision of novel cell and animal models as well as clinically validated biomarkers directly relevant for development of early diagnosis and treatment of Parkinson’s disease and Alzheimer’s disease. These are essential steps in the strategy towards a rational design of new drugs that induce neural repair and/or prevent nervous degeneration. All findings will be verified directly in post-mortem human brain material of Parkinson and Alzheimer patients and in a large collection of CSF from the Netherlands Brain Bank and the VU University Medical Center.
Partners: Abbott, DNage BV, Erasmus MC (University Medical Center Rotterdam), Leiden University Medical Center, Netherlands Institute for Neuroscience, University Medical Center Utrecht, Utrecht University, VU University Amsterdam, and VU University Medical Center
Full project title: Parkinson and Alzheimer disease: from dysregulated human brain targets towards novel therapeutics