Projects
CSF proteome/metabolome and CNS disorders
The goal of this project is to develop robust procedures for biomarker discovery in rodent and human cerebrospinal fluid (CSF), and to use this approach to discover, validate, and quantify metabolome and proteome biomarkers in CSF so that drug-related exposure and efficacy for neurological (e.g. multiple sclerosis, Alzheimer’s disease) and psychiatric diseases (e.g. schizophrenia, depression) can be predicted. In 2008, protocols for proteomics and metabolomics approaches for the analysis of human and rat CSF were developed. Also, clinical CSF samples of multiple sclerosis patients were studied using metabolomics and proteomics.
Partners: Abbott, Erasmus MC (University Medical Center Rotterdam), Leiden University, MSD, Radboud University Nijmegen, TNO, and the University of Groningen
Full project title: The CSF proteome / metabolome as primary biomarker compartment for CNS disorders