Projects
Osteoarthritis and patient stratification
This TI Pharma research project is being conducted by a consortium consisting of Osteoarthritis is the most common joint disorder, especially in the elderly. Little is known about its etiology and pathophysiology, and no treatments are available. In its Priority Medicines Report, the WHO calls for additional research. Yet which patients will develop rapidly progressing osteoarthritis and why this happens is not known. The current project will investigate the role of synovium and fat tissue in osteoarthritis development and progression. The ultimate goal is to optimize the efficiency of clinical trials for osteoarthritis by improving patient stratification, understanding disease mechanisms and predicting disease outcome.
Partners: Centocor, Erasmus MC (University Medical Center Rotterdam), Leiden University Medical Center, and TNO
Full project title: Osteoarthritis: models, mechanisms and markers for patient stratification